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Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.
Gene Name: | HIV-1 Tat specific factor 1 |
Synonyms: | HTATSF1, HIV TAT specific factor 1, HIV Tat-specific factor 1, HIV-1 Tat specific factor 1, TAT-SF1, DJ196E23.2 |
Target Sequences: | NM_014500 NP_055315.2 O43719 |
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