Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 718-238] (IgG2b) to Human Papillomavirus HPV18 E7
Western blot, ELISA
Human Papillomavirus HPV18 E7
Human Papillomavirus (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [718-238]
Specificity and Use
HPV18 E7 antibody was raised against oncoprotein E7 from human papillomavirus 18.
Recognizes the E7 oncoprotein of human papilloma virus 18. Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupts normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-suppressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. May be used to detect the E7 protein of HPV-16 in ELISA assays. Does not cross-react with the E7 protein of HPV-16.
ELISA: This product may be used in an indirect ELISA or as a detection antibody in a sandwich ELISA together with LS-C58370 as a capture reagent.