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Anti-HPV18 E7 Antibody (clone 718-15) LS-C58370

Ordering

Wt. Vol. Conc. Price
200 µg - - $370
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
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Anti-HPV18 E7 Antibody LS-C319021
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100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 718-15] (IgG1) to Human Papillomavirus HPV18 E7
Human Papillomavirus
Western blot, ELISA
Unconjugated

Details

Human Papillomavirus HPV18 E7
Mouse
Human Papillomavirus (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [718-15]
Unconjugated
Affinity purified
Unmodified

Applications

  • Western blot
  • ELISA

Specificity and Use

HPV18 E7 antibody was raised against oncoprotein E7 from human papillomavirus 18.
Recognizes the E7 oncoprotein of human papilloma virus 18. Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupts normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-suppressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection. May be used as a capture antibody in ELISA assays for the E7 protein of HPV-18.
ELISA: This product may be used in an indirect ELISA or as a capture antibody in a sandwich ELISA together with LS-C58371 as a detection reagent.

Packaging

PBS, pH 7.2, 0.09% sodium azide.
Long term: -20°C; Short term: -20°C
For research use only.

About HPV18 E7


Requested From: United States
Date Requested: 12/9/2016

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