Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 718-15] (IgG1) to Human Papillomavirus HPV18 E7
Western blot, ELISA
Human Papillomavirus HPV18 E7
Human Papillomavirus (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [718-15]
Specificity and Use
HPV18 E7 antibody was raised against oncoprotein E7 from human papillomavirus 18.
Recognizes the E7 oncoprotein of human papilloma virus 18. Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupts normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-suppressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection. May be used as a capture antibody in ELISA assays for the E7 protein of HPV-18.
ELISA: This product may be used in an indirect ELISA or as a capture antibody in a sandwich ELISA together with LS-C58371 as a detection reagent.