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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.
Gene Name: | homeobox A5 |
Synonyms: | HOXA5, Homeo box A5, Homeobox A5, Homeo box 1C, Homeobox protein Hox-1C, HOX1, Homeobox protein Hox-A5, Homeobox protein HOXA5, HOX1.3, HOX1C |
Target Sequences: | NM_019102 NP_061975.2 P20719 |
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