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Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.
Gene Name: | HORMA domain containing 1 |
Synonyms: | HORMAD1, CT46, Cancer/testis antigen 46, DKFZP434A1315, Newborn ovary HORMA protein, NOHMA, HORMA domain containing 1 |
Target Sequences: | AL136755 CAB66689.1 Q86X24 |
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