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Anti-HMOX1 / HO-1 Antibody (aa12-25) LS-C11351

Note: This antibody replaces LS-C123732

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $550
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Rabbit Polyclonal (IgG) to Human HMOX1 / HO-1
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Pig, Xenopus
IHC - Frozen, Western blot
Unconjugated

Details

Human HMOX1 / HO-1
Rabbit
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Pig, Xenopus (tested or 100% immunogen sequence identity)
Chicken (at least 90% immunogen sequence identity)
Dog
IgG Polyclonal
Purified IgG

Applications

IHC - Frozen, Western blot (1:500 - 1:2000)

Specificity and Use

HMOX1 / HO-1 antibody was raised against synthetic peptide with the amino acid sequence DLSEALKEATKEVHC corresponding to residues 12-25 of human heme oxygenase 1. Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Pig, Opossum, Platypus, Xenopus (100%); Turkey, Chicken, Lizard (93%).
aa12-25
Recognizes human heme oxygenase-1 (HO-1), a 288 amino acid enzyme with a crucial role in heme catabolism, cleaving the heme ring to form biliverdin which is further processed to form bilirubin by a reductase enzyme. HO-1 acitivity is highest in the spleen where it is involved in the processing of senescent erythrocytes. HO-1expression can be increased during cellular stress, including heat shock. Baseline levels of expression are high in certain tissues, including spleen and liver. Enriched enzyme preparations are recommended for experimental analysis.
Western Blot: Heme oxygenase 1 demonstrates a single band of approximately 32kD. Immunohistology: LS-C11351 reacts with human spleen, kidney and airway biopsies, as well as pig arteries.

Packaging

PBS, 0.09% sodium azide.
Long term: -20°C; Short term: -20°C
For research use only.

About HMOX1 / HO-1

P09601 NM_002133 NP_002124.1

HMOX1 Antibody, BK286B10 Antibody, HO-1 Antibody, HSP32 Antibody, Heat shock protein, 32-kD Antibody, Heme oxygenase (decycling) 1 Antibody, Heme oxygenase 1 Antibody, HO1 Antibody

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.

Requested From: United States
Date Requested: 9/29/2016

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