Human HMOX1 / HO-1

Rabbit

Human (tested or 100% immunogen sequence identity)

Dog

IgG Polyclonal

Unconjugated

Purified IgG

Unmodified

Synthetic peptide with the amino acid sequence DLSEALKEATKEVHC corresponding to residues 12-25 of human heme oxygenase 1. Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Pig, Opossum, Platypus, Xenopus (100%); Turkey, Chicken, Lizard (93%).

aa12-25

Recognizes human heme oxygenase-1 (HO-1), a 288 amino acid enzyme with a crucial role in heme catabolism, cleaving the heme ring to form biliverdin which is further processed to form bilirubin by a reductase enzyme. HO-1 acitivity is highest in the spleen where it is involved in the processing of senescent erythrocytes. HO-1expression can be increased during cellular stress, including heat shock. Baseline levels of expression are high in certain tissues, including spleen and liver. Enriched enzyme preparations are recommended for experimental analysis.

• IHC - Frozen
• Western blot (1:500 - 1:2000)

Western Blot: Heme oxygenase 1 demonstrates a single band of approximately 32kD. Immunohistology: LS-C11351 reacts with human spleen, kidney and airway biopsies, as well as pig arteries.

PBS, 0.065% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P09601 NCBI: NM_002133 NP_002124.1