Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Specificity and Use
HLA-E antibody was raised against bacterially expressed recombinant full length protein refolded with beta2-microglobulin and peptide (Human).
The antibody recognized native surface-expressed HLA E, but not denatured heavy chain of HLA E. The published results showed that the antibody cross-reacts with some classical MHC Class I molecules (HLA A3, A11, B7). However, the recent Workshop I Session on the 3rd International Conference on HLA-G (Paris, July 2003) confirmed that the antibody exhibits much broader cross-reactivity classical MHC Class I antigens, namely with HLA A24, A32, B8, B15, B27, B35, B44, B54, C3, C4, C5 and C7. Species cross-reactivity: Cross-reacts with Human.
Suitable for use in Flow Cytometry and Immunoprecipitation.