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This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
Gene Name: | Human Immunodeficiency Virus type I Enhancer binding protein 1 |
Synonyms: | HIVEP1, CIRIP, CRYBP1, Cirhin interaction protein, GAAP, HIV-EP1, MBP-1, Schnurri-1, Zinc finger protein 40, ZNF40A, ZAS1, ZNF40, PRDII-BF1 |
Target Sequences: | NM_002114 NP_002105.3 P15822 |
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