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Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
Gene Name: | histone deacetylase 8 |
Family/Subfamily: | Histone Deacetylase , not assigned-Histone Deacetylase |
Synonyms: | HDAC8, CDLS5, HD8, HDACL1, Histone deacetylase 8, MRXS6, RPD3, CDA07, Histone deacetylase-like 1, WTS |
Target Sequences: | NM_018486 NP_060956.1 Q9BY41 |
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