Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Gene Name: | hydroxycarboxylic acid receptor 2 |
Family/Subfamily: | GPCR , Nicotinic acid |
Synonyms: | HCAR2, GPR109A, HCA2, NIACR1, Nicotinic acid receptor, HM74a, HM74b, Niacin receptor 1, Puma-g, PUMAG |
Target Sequences: | AB083632 BAB89345.1 Q8TDS4 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.