Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone LUEE] (IgG2a,k) to Mouse GZMB / Granzyme B
Mouse GZMB / Granzyme B
Mouse (tested or 100% immunogen sequence identity)
IgG2a,k Monoclonal [LUEE]
Specificity and Use
GZMB / Granzyme B antibody was raised against mouse GZMB
The LUEE antibody has been tested as the detection antibody in a sandwich ELISA for analysis of mouse granzyme B in combination with the purified 16G6 antibody for capture and recombinant mouse granzyme B as the standard. A suitable range of concentrations of this antibody for ELISA detection is 0.5-2 ug/ml. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.