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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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GZMB / Granzyme B Antibody (aa7‑227, clone B18.1) LS‑C24027
Granzyme B antibody LS-C24027 is an unconjugated mouse monoclonal antibody to human Granzyme B (GZMB). Validated for Flow, IHC, IP and WB.
Antibody
Catalog
Size
Price
LS-C24027-100
100 µg
$545

Popular GZMB / Granzyme B Products

Antibody
Species: Human, Monkey, Rhesus monkey
Applications: IHC, IHC - Frozen, Immunoprecipitation, Flow Cytometry, ELISA
IHC of paraffin-embedded Human Kidney tissue using anti-GZMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot
Anti-GZMB / Granzyme B antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2783 concentration 10 ug/ml.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin
Antibody
Species: Human, Monkey, Rhesus monkey
Applications: IHC, IHC - Frozen, Immunoprecipitation, Flow Cytometry, ELISA
Anti-GZMB / Granzyme B antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7602 dilution 1:100.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay

Product Description

Granzyme B antibody LS-C24027 is an unconjugated mouse monoclonal antibody to human Granzyme B (GZMB). Validated for Flow, IHC, IP and WB.
About GZMB / Granzyme B
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. P10144 NM_004131 NP_004122.2

GZMB Antibody, CCPI Antibody, CGL-1 Antibody, Cathepsin G-like 1 Antibody, CSP-B Antibody, CTLA-1 Antibody, CTLA1 Antibody, CGL1 Antibody, CSPB Antibody, Fragmentin 2 Antibody, GRB Antibody, HLP Antibody, Human lymphocyte protein Antibody, Fragmentin-2 Antibody, SECT Antibody, Lymphocyte protease Antibody, T-cell serine protease 1-3E Antibody, C11 Antibody, CTSGL1 Antibody, Cytotoxic serine protease B Antibody, Granzyme B Antibody, Granzyme-2 Antibody


Specifications

Target
Human GZMB / Granzyme B
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [B18.1]
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Applications
  • IHC
  • Western blot
  • Immunoprecipitation
  • Flow Cytometry
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Human recombinant granzyme B (aa7-227).
Epitope
aa7-227
Specificity
Recognizes human Granzyme B, a 27kD protein.
Usage
Suitable for use in Western blot, Immunoprecipitation, Flow Cytometry, and Immunohistochemistry.
Presentation
PBS, 1.5 mM Sodium Azide, 1 mg/ml BSA, 50% Glycerol
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.

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Requested From: United States
Date Requested: 9/19/2018

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