Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.
Gene Name: | glycoprotein Ib (platelet), alpha polypeptide |
Synonyms: | GP1BA, Antigen CD42b-alpha, CD42b antigen, BDPLT3, CD42b-alpha, DBPLT3, Glycoprotein Ibalpha, GPIbA, GP-Ib alpha, gp1B, GPIb-alpha, BDPLT1, BSS, CD42B, gp1BA, VWDP |
Target Sequences: | NM_000173 NP_000164.5 P07359 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.