Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
GCK Antibody, FGQTL3 Antibody, Glucokinase Antibody, HK IV Antibody, HKIV Antibody, Hexokinase d, liver isozymes Antibody, Hexokinase-4 Antibody, Hexokinase-D Antibody, HXKP Antibody, GLK Antibody, Glucokinase (hexokinase 4) Antibody, Hexokinase type IV Antibody, HHF3 Antibody, HK4 Antibody, LGLK Antibody, MODY2 Antibody
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of hGCK-S418 in Jurkat cell line lysates (35 ug/lane). GCK (arrow) was detected using the purified antibody.
Western blot of GCK (arrow) using rabbit polyclonal hGCK-S418. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GCK gene.