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GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
Gene Name: | GTP cyclohydrolase I feedback regulator |
Synonyms: | GCHFR, p35, GFRP, HsT16933 |
Target Sequences: | NM_005258 NP_005249.1 P30047 |
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