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Chromosomal region 7p12, which contains GBAS, is amplified in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumor. The predicted 286-amino acid protein contains a signal peptide, a transmembrane domain, and 2 tyrosine phosphorylation sites. The GBAS transcript is expressed most abundantly in heart and skeletal muscle. GBAS protein might be involved in vesicular transport.
Gene Name: | glioblastoma amplified sequence |
Synonyms: | GBAS, NIPSNAP2, Protein NipSnap homolog 2 |
Target Sequences: | NM_001483 NP_001474.1 O75323 |
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