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GAPDHS / GAPDS is a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.
Gene Name: | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic |
Synonyms: | GAPDHS, GAPD2, GAPDH2, GAPDS, GAPDH-2, HSD-35 |
Target Sequences: | NM_014364 NP_055179.1 O14556 |
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