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Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Gene Name: | fyn-related kinase |
Family/Subfamily: | Protein Kinase , Src |
Synonyms: | FRK, BSK/IYK, BSK, Fyn-related kinase, GTK, PTK5 protein tyrosine kinase 5, RAK, Tyrosine-protein kinase FRK, Protein-tyrosine kinase 5, PTK5 |
Target Sequences: | NM_002031 NP_002022.1 P42685 |
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