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Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
Gene Name: | F-box protein 46 |
Synonyms: | FBXO46, 20D7-FC4, FBXO34L, F-box only protein 46, F-box protein 46, Fbx46, F-box only protein 34-like |
Target Sequences: | NM_001080469 NP_001073938.1 Q6PJ61 |
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