Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG1,k) to Bovine FBN1 / Fibrillin 1
IHC, Immunofluorescence, Western blot
Bovine FBN1 / Fibrillin 1
Bovine (tested or 100% immunogen sequence identity)
IHC (1:50 - 1:100)
Western blot (1 µg/ml)
Specificity and Use
Microfibrils from zonular apparatus of bovine eye.
Recognizes bovine fibrillin (Mr 350kD). Species cross-reactivity: Human.
Immunohistochemistry. Immunofluorescence. Western Blot. Electron microscopic immunolocalization. Immunohistochemistry: 1:50-1:100 (30-60 min at RT). Western Blot: 1 ug/ml. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, sodium azide.
Short term: +4°C; Long term: Add glycerol (40-50%) -20°C.
Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.