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EXOSC6

exosome component 6

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

Gene Name: exosome component 6
Synonyms: EXOSC6, Exosome complex component MTR3, Exosome component 6, HMtr3, HMtr3p, p11, MTR3, EAP4, Mtr3p
Target Sequences: NM_058219 NP_478126.1 Q5RKV6

☰ Filters
Antibodies (15)
Proteins (3)
Over-Expression Lysate (2)
Primary (15)
Recombinant (1)
EXOSC6 (18)
Human (15)
Mouse (3)
Rat (3)
Bat (3)
Bovine (3)
Chimpanzee (6)
Monkey (6)
IHC (4)
IHC-P (4)
WB (15)
ELISA (6)
rabbit (15)
IgG (14)
polyclonal pc (15)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (4)
N-Terminus (8)
aa12-38 (7)
No (18)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
EXOSC6 Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
EXOSC6 Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Mouse, Bovine, Rat, Bat, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
EXOSC6 Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Bovine, Rat, Bat, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
EXOSC6 Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Mouse, Bovine, Rat, Bat, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
EXOSC6 Antibody - EXOSC6 antibody ARP41087_T100-NP_478126-EXOSC6 (exosome component 6) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
EXOSC6 Antibody - EXOSC6 antibody ARP41087_T100-NP_478126-EXOSC6 (exosome component 6) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
EXOSC6 Antibody - EXOSC6 antibody ARP41087_T100-NP_478126-EXOSC6 (exosome component 6) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
EXOSC6 Antibody - EXOSC6 antibody ARP41087_T100-NP_478126-EXOSC6 (exosome component 6) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
Select
EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
EXOSC6 Antibody - EXOSC6 Antibody western blot of WiDr cell line lysates (35 ug/lane). The EXOSC6 antibody detected the EXOSC6 protein (arrow).
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EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) Antibody
Human
WB
Unconjugated
400 µl/$393
EXOSC6 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
EXOSC6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
28.2 kDa
20 µg/$150
EXOSC6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
28.2 kDa
100 µg/$494
Viewing 1-18 of 18 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).