EXOSC6

exosome component 6

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

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Products

Antibodies (15)

Proteins (3)

Type

Over-Expression Lysate (2)

Primary (15)

Recombinant (1)

Target

EXOSC6 (18)

Reactivity

Human (15)

Mouse (3)

Rat (3)

Bat (3)

Bovine (3)

Chimpanzee (6)

Monkey (6)

Application

IHC (4)

IHC-P (4)

WB (15)

ELISA (6)

Host

rabbit (15)

Isotype

IgG (14)

Clonality

polyclonal pc (15)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (4)

Epitope

N-Terminus (8)

aa12-38 (7)

Publications

No (18)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Select

EXOSC6 Antibody (N-Terminus) LS-C30332

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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EXOSC6 Antibody (N-Terminus, HRP) LS-C441564

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Mouse, Bovine, Rat, Bat, Chimpanzee, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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EXOSC6 Antibody (N-Terminus, Biotin) LS-C441562

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Mouse, Bovine, Rat, Bat, Chimpanzee, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

EXOSC6 Antibody (N-Terminus, FITC) LS-C441563

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Mouse, Bovine, Rat, Bat, Chimpanzee, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

EXOSC6 Antibody (N-Terminus) LS-C30677

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$397

Select

EXOSC6 Antibody (N-Terminus, HRP) LS-C441567

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$442

Select

EXOSC6 Antibody (N-Terminus, Biotin) LS-C441565

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$442

Select

EXOSC6 Antibody (N-Terminus, FITC) LS-C441566

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$442

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

EXOSC6 Antibody (aa12-38) LS-C329521

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

EXOSC6 Antibody (aa12-38, Biotin) LS-C235099

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

EXOSC6 Antibody (aa12-38, FITC) LS-C235100

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

EXOSC6 Antibody (aa12-38, APC) LS-C235098

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

EXOSC6 Antibody (aa12-38, PE) LS-C235101

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

EXOSC6 Antibody (aa12-38, Azide-free, HRP) LS-C249943

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

EXOSC6 Antibody (aa12-38) LS-C159579

Antibody:

EXOSC6 Rabbit anti-Human Polyclonal (aa12-38) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

Human EXOSC6 Protein (Recombinant GST, N-terminus) (aa3-66) - LS-G63595

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human EXOSC6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92998

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.2 kDa

Price:

20 µg/$150

Select

EXOSC6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107940

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.2 kDa

Price:

100 µg/$494

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