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Anti-EPOR / EPO Receptor Antibody (Extracellular Domain) LS-C187856

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $310
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
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Most Popular EPOR / EPO Receptor Antibodies

Anti-EPOR / EPO Receptor Antibody (Extracellular Domain) LS-C84005
Sheep Polyclonal to Human EPOR / EPO Receptor
Human, Mouse
IHC, ICC, Western blot, Immunoprecipitation, ELISA
Unconjugated
Anti-EPOR / EPO Receptor Antibody (clone 12K90, APC) LS-C182845
Mouse Monoclonal [clone 12K90] (IgG1) to Human EPOR / EPO Receptor
Human
Flow Cytometry
APC Conjugated
Anti-EPOR / EPO Receptor Antibody (clone 12K92, PE) LS-C182846
Mouse Monoclonal [clone 12K92] (IgG1) to Human EPOR / EPO Receptor
Human
Flow Cytometry
PE Conjugated

100% Guaranteed 100% Guaranteed
Sheep Polyclonal (IgG) to Human EPOR / EPO Receptor
Human, Mouse
Western blot, Immunoprecipitation, ELISA
Unconjugated

Details

Human EPOR / EPO Receptor
Sheep
Human, Mouse (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Affinity purified
Unmodified

Applications

  • Western blot (10 µg/ml)
  • Immunoprecipitation (10 µg/ml)
  • ELISA

Specificity and Use

EPOR / EPO Receptor antibody was raised against partial cDNA of the extracellular domain of human EpoR expressed as a GST fusion protein in E. coli.
Extracellular Domain
Recognizes Erythropoietin Receptor (EPOR), a type I transmembrane protein and member of the type I cytokine receptor family, expressed by erythroid cells and erythroid progenitor cells, which acts as a receptor for erythropoietin (EPO) to mediate erythroblast proliferation and differentiation, and maintain progenitor survival. Binding of EPO to EPOR, results in the dimerization of the EPOR and the triggering of the JAK2/STAT5 signaling cascade, and in some cell types activation of STAT1 and STAT3. Several isoforms of EPOR exist: EPOR-F, EPOR-S and EPOR-T, and a functional EPOR is found on endothelial cells and cardiomyocytes within the cardiovascular system, suggesting a role in cardiac function. AHP1825 has been shown to block Iodine125 labeled erythropoietin ligand binding using erythroleukemia cell line TF-1 with 3000 EPOR/cell in neutralization studies, see for details. AHP1825 is reported as suitable for use in immunocytochemistry. AHP1825 has been reported for use in functional studies. Removal of Sodium Azide is recommended prior to use in functional assays. The recommended concentration for functional assays is 500 ug/ml.

Packaging

PBS, 0.09% sodium azide
Store at 4°C. Do not freeze.
For research use only.

About EPOR / EPO Receptor

P19235 NM_000121 NP_000112.1

EPOR Antibody, EPO Receptor Antibody, EPO-R Antibody, Erythropoietin receptor Antibody

EPOR / EPO Receptor is the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis.

Requested From: United States
Date Requested: 12/4/2016

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