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Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.
Gene Name: | ELK4, ETS-domain protein (SRF accessory protein 1) |
Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
Synonyms: | ELK4, SAP-1, SAP1, SRF accessory protein 1 |
Target Sequences: | NM_021795 NP_068567.1 P28324 |
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