Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation
Rabbit Polyclonal to Human EGFR
Human, Mouse, Rat
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Specificity and Use
EGFR antibody was raised against peptide mapping to a sequence near the carboxy terminus of human EGFR.
EGFR of mouse, rat, and human origin by western blotting, immunoprecipitation, and immunohistochemistry (including paraffin-embedded sections). Western blotting starting dilution: 1:200. A431 lysates can be used as a positive control.
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues.