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Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).
Gene Name: | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B |
Family/Subfamily: | Protein Kinase , MNB/DYRK |
Synonyms: | DYRK1B, Mirk protein kinase, Minibrain-related kinase, MIRK |
Target Sequences: | NM_004714 NP_004705.1 Q9Y463 |
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