Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
DUX4 Antibody, Double homeobox protein 10 Antibody, Double homeobox protein DUX10 Antibody, Double homeobox 4 Antibody, Double homeobox protein 4/10 Antibody, Double homeobox protein 4 Antibody, DUX10 Antibody
DUX4 is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307).
DUX4 Antibody (P4H2) - IHC of DUX4 on human testis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
DUX4 Antibody (P4H2) - Immunofluorescence detection of human DUX4 on C2C12 mouse myoblasts transfected with pCS2-DUX4. Cells were counterstained with DAPI for nuclei. This image was taken for the unconjugated form of this product. Other forms have not been tested.
DUX4 Antibody (P4H2) - Western blot of DUX4 expression in 1) human testis and 2) DUX4 protein lysates. This image was taken for the unconjugated form of this product. Other forms have not been tested.