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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DSG1+2 / Desmoglein 1+2 Antibody (C‑Terminus) LS‑C22811
Desmoglein 1+2 antibody LS-C22811 is an unconjugated mouse monoclonal antibody to Desmoglein 1+2 (DSG1+2) from human, mouse, rat and other species. Validated for IF, IHC and WB.
Antibody
Catalog
Size
Price
LS-C22811-50
50 µg (0.05 mg/ml)
$620

Popular DSG1+2 / Desmoglein 1+2 Products

Antibody
Species: Bovine
Applications: IHC, IHC - Paraffin, IHC - Frozen

Product Description

Desmoglein 1+2 antibody LS-C22811 is an unconjugated mouse monoclonal antibody to Desmoglein 1+2 (DSG1+2) from human, mouse, rat and other species. Validated for IF, IHC and WB.

Specifications

Target
Bovine DSG1+2 / Desmoglein 1+2
Host
Mouse
Reactivity
Bovine, Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • IHC - Frozen
  • Immunofluorescence
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Band 3 polypeptide of isolated desmosomes from bovine muzzle epidermis.
Epitope
C-Terminus
Specificity
Species (tested so far) Human, bovine, rat, mouse. Recognizes desmoglein 1 + 2 (desmosome-specific cadherins) in desmosome-bearing cells; does not react with cells containing plaque-bearing junctions of non-desmosomal type. Tumors specifically detected: all epithelium-derived tumors, notably carcinomas, and meningiomas. Polypeptide reacting: Mr 165000 Desmoglein, 'band 3' polypeptide of the desmosomal complex. Epitope recognized has been localized at the repeating unit domain ('RUD') of the cytoplasmic C-terminal part of the polypeptide. Reactivities on Cultured Cell Lines (tested so far): A-431, MCF-7, TR-146, PLC and various other human epithelial cell lines; bovine BMGE+H, BMGE-H, MDBK.
Usage
Suitable for use in Immunohistochemistry (frozen sections, paraffin-embedded tissue after microwave treatment), Western Blot; Cryo, Paraffin (Microwave), Immunofluorescence microscopy. Immunohistochemistry: 1:10 with PBS, pH 7.4; Incubation Time 1 h at RT; extended with paraffin.
Presentation
Lyophilized
Reconstitution
deionized water
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.

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Requested From: United States
Date Requested: 9/19/2018

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