Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Human DSC2 / Desmocollin 2
IHC - Paraffin, Western blot
Human DSC2 / Desmocollin 2
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin (1:100 - 1:1000)
Western blot (1:500 - 1:3000)
Specificity and Use
DSC2 / Desmocollin 2 antibody was raised against recombinant fragment corresponding to a region within amino acids 480 and 706 of Desmocollin 2 (SwissProt Q02487). Percent identity by BLAST analysis: Human (100%); Mouse (80%).
Human Desmocollin 2 / DSC2
IHC-paraffin: Suggested antigen retrieval using heat mediated 10 mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0).
0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal
Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
DSC2 Antibody, ARVD11 Antibody, CDHF2 Antibody, Cadherin family member 2 Antibody, Desmosomal glycoprotein III Antibody, DG2 Antibody, DGII/III Antibody, Desmocollin-2 Antibody, Desmocollin-3 Antibody, Desmosomal glycoprotein II Antibody, Desmosomal glycoprotein II/III Antibody, Desmocollin 2 Antibody
DSC2 / Desmocollin 2 is a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18.