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DP97 / DDX54 is a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene.
Gene Name: | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 |
Family/Subfamily: | DEAD box protein |
Synonyms: | DDX54, APR-5, DEAD box protein 54, DEAD box helicase 97 KDa, DP97, DEAD box RNA helicase 97 kDa |
Target Sequences: | NM_024072 NP_076977.3 Q8TDD1 |
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