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Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
Gene Name: | DnaJ (Hsp40) homolog, subfamily C, member 3 |
Synonyms: | DNAJC3, ERdj6, HP58, p58, PRKRI, Protein kinase inhibitor p58, p58IPK |
Target Sequences: | NM_006260 NP_006251.1 Q13217 |
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