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Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).
Gene Name: | DnaJ (Hsp40) homolog, subfamily A, member 1 |
Synonyms: | DNAJA1, DNAJ2, HDJ-2, HDJ2, HSJ2, HSPF4, Human DnaJ protein 2, NEDD7, HSDJ, DJ-2, DjA1, DnaJ protein homolog 2, Heat shock 40 kDa protein 4, Heat shock protein J2, HSJ-2 |
Target Sequences: | NM_001539 NP_001530.1 P31689 |
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