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Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.
Gene Name: | discs, large homolog 2 (Drosophila) |
Family/Subfamily: | MAGUK , Not assigned-Other |
Synonyms: | DLG2, Chapsyn-110, Disks large homolog 2, PPP1R58, PSD-93, PSD93 |
Target Sequences: | NM_001364 NP_001355.2 Q15700 |
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