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Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).
Gene Name: | diacylglycerol O-acyltransferase 2 |
Synonyms: | DGAT2, ARAT, Diglyceride acyltransferase 2, GS1999FULL, HMFN1045 |
Target Sequences: | NM_032564 BAB40641.2 Q96PD7 |
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