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Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression.
Gene Name: | DCN1, defective in cullin neddylation 1, domain containing 1 |
Synonyms: | DCUN1D1, DCN1-like protein 1, DCNL1, DCUN1L1, RP42 homolog, RP42, Tes3, SCCRO, SCRO |
Target Sequences: | NM_020640 NP_065691.2 Q96GG9 |
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