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CYP24 / CYP24A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | cytochrome P450, family 24, subfamily A, polypeptide 1 |
Family/Subfamily: | Cytochrome P450 , not assigned-Cytochrome P450 |
Synonyms: | CYP24A1, 24-OHase, CP24, CYP24, Cytochrome P450-CC24, Exo-mitochondrial protein, HCAI, p450-CC24, Vitamin D 24-hydroxylase, Cytochrome P450 24A1, Vitamin D(3) 24-hydroxylase |
Target Sequences: | NM_000782 NP_000773.2 Q07973 |
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