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Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.
Gene Name: | platelet factor 4 |
Family/Subfamily: | Intercrine , Intercrine alpha |
Synonyms: | PF4, C-X-C motif chemokine 4, CXCL4, Iroplact, Oncostatin-A, PF-4, SCYB4, Platelet factor 4 |
Target Sequences: | NM_002619 NP_002610.1 P02776 |
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