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Anti-CUL1 / Cullin 1 Antibody (C-Terminus) IHC-plus™ LS-B357

Note: This antibody replaces LS-C18779

Ordering

Wt. Vol. Conc. Price
- 50 µl 85 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CUL1 / Cullin 1 Antibodies

Anti-CUL1 / Cullin 1 Antibody (clone AS97.1) LS-C63155
Mouse Monoclonal [clone AS97.1] (IgG2a) to Human CUL1 / Cullin 1
Human, Monkey, Mouse, Rat, Bovine, Rabbit
Western blot
Unconjugated
Anti-CUL1 / Cullin 1 Antibody (C-Terminus) IHC-plus™ LS-B2448
Mouse Monoclonal (IgG1,k) to Human CUL1 / Cullin 1
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (2)
Rabbit Polyclonal to Human CUL1 / Cullin 1
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated

Details

Human CUL1 / Cullin 1
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Delipidated and defibrinated
Unmodified

Applications

  • IHC - Paraffin (1:500)
  • Western blot (1:500 - 1:1000)
  • Immunoprecipitation
  • ELISA (1:2000 - 1:10000)

Specificity and Use

CUL1 / Cullin 1 antibody was raised against synthetic peptide from human CUL1 / Cullin 1.
C-Terminus
Human Cul1.
Immunohistochemistry: LS-B357 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B357 was determined to be 1:500.

Packaging

0.01% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

Publications (2)

1
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM. Cell. 1996 85:829-39. [PubMed:8681378]
2
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Ohta T, Michel JJ, Schottelius AJ, Xiong Y. Molecular cell. 1999 3:535-41. [PubMed:10230407]

About CUL1 / Cullin 1

Q13616 NM_003592 NP_003583.2

CUL1 Antibody, Cullin 1 Antibody, Cullin-1 Antibody, CUL-1 Antibody

Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.

Immunohistochemistry

Immunohistochemistry
Anti-CUL1 / Cullin 1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B357 dilution 1:500.
 

Requested From: United States
Date Requested: 12/2/2016

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