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Plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Gene Name: | cytosolic thiouridylase subunit 1 |
Synonyms: | CTU1, ATPBD3, ATP binding domain 3, Cancer-associated protein, Cancer-associated gene protein, NCS6 |
Target Sequences: | Q7Z7A3 Q7Z7A3 |
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