Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
Western blot (1:16000) & (1 - 3 µg/ml)
IHC - Paraffin
Specificity and Use
CTSK / Cathepsin K antibody was raised against synthetic peptide C-KTHRKQYNNKVDE from an internal region (near N-terminus) of human CTSK / Cathepsin K (NP_000387.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset (92%); Mouse, Rat, Dog, Horse, Pig (85%).
CTSK Antibody, Cathepsin K Antibody, Cathepsin K (pycnodysostosis) Antibody, Cathepsin O1 Antibody, Cathepsin O2 Antibody, Cathepsin X Antibody, CTSO2 Antibody, PKND Antibody, Procathepsin K Antibody, PYCD Antibody, Cathepsin O Antibody, CTS02 Antibody, CTSO1 Antibody
CTSK / Cathepsin K is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.