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Anti-CTSB / Cathepsin B Antibody (HRP) LS-C187625

Ordering

Wt. Vol. Conc. Price
- 1000 µl 1 mg/ml $305
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CTSB / Cathepsin B Antibodies

Anti-CTSB / Cathepsin B Antibody IHC-plus™ LS-B3313
Rabbit Polyclonal to Human CTSB / Cathepsin B
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-CTSB / Cathepsin B Antibody (FITC) LS-C211773
Rabbit Polyclonal (IgG) to Human CTSB / Cathepsin B
Human
IHC, Western blot, ELISA
FITC Conjugated

100% Guaranteed 100% Guaranteed
Sheep Polyclonal (IgG) to Human CTSB / Cathepsin B
Human
ELISA
HRP Conjugated

Details

Human CTSB / Cathepsin B
Sheep
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Horseradish Peroxidase
Protein G purified
Unmodified

Applications

ELISA (1:500 - 1:1000)

Specificity and Use

CTSB / Cathepsin B antibody was raised against native cathepsin B from placenta.
Detects cathepsin B, a lysosomal cysteine protease which functions as both a endopeptidase and a carboxypeptidase. Together with cathepsins D and L, cathepsin B is one of the most abundant proteases in the lysosome, and participates in intracellular protein degradation. Cathepsin B is thought to play an increasingly important role in apoptosis and its release from the lysosome under cell stress leads to Bid cleavage, cytochrome C release and nuclear fragmentation. Cathepsin B is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete processing of APP is thought to be a causative factor in Alzheimer disease. Over-expression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors, and has in particular been implicated in tumor invasion and metastasis.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

PBS, 0.01% Thimerosal, HRP stabilizer
Store at 4°C. Do not freeze.
For research use only.

About CTSB / Cathepsin B

P07858 NM_001908 NP_001899.1

CTSB Antibody, Cathepsin B1 Antibody, Cathepsin B Antibody, Cathepsins B Antibody, CPSB Antibody, Cysteine protease Antibody, Preprocathepsin B Antibody, APP secretase Antibody, APPS Antibody

Cathepsin B is a lysosomal cysteine proteinase synthesized as a zymogen of 39-47 kilodaltons (kD), which is subsequently converted into an active single- chain form of 33 kD (CB33) and, by additional processing, into the active 2-chain form containing a heavy chain of 27-29 kD (CB(27-29)) and a light chain of 4-6 kD.

Enzyme-Linked Immunosorbent Assay

Enzyme-Linked Immunosorbent Assay
Cathepsin B detected with Sheep anti-Cathepsin B:HRP This image was taken for the unconjugated form of this product. Other forms have not been tested.
 

Requested From: United States
Date Requested: 12/5/2016

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