Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
CRYAB / Alpha B Crystallin antibody was raised against a synthetic peptide made to a C-terminal region of the human Crystallin AB protein (within residues 100-175). [Swiss-Prot P02511] Percent identity by BLAST analysis: Rat (100%); Mouse (92%).
Crystallin AB protein.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
CRYAB Antibody, Alpha-crystallin B chain Antibody, CRYA2 Antibody, Crystallin, alpha B Antibody, CTPP2 Antibody, Heat shock protein beta-5 Antibody, HSPB5 Antibody, Alpha B Crystallin Antibody, Alpha(B)-crystallin Antibody, Rosenthal fiber component Antibody, Heat-shock 20 kD like-protein Antibody
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates.
Detection of CryAB using antibody at 0.5 ug/ml. Lane 1: Human skeletal muscle Lane 2: Mouse skeletal muscle. This image was taken for the unconjugated form of this product. Other forms have not been tested.