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CR6 / GADD45G is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta.
Gene Name: | growth arrest and DNA-damage-inducible, gamma |
Synonyms: | GADD45G, CR6, DDIT2, GADD45-gamma, GADD45gamma, Gadd-related protein, 17 kD, GRP17, DDIT-2 |
Target Sequences: | NM_006705 NP_006696.1 O95257 |
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