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Human Complement C3 | |
Mouse | |
Human (tested or 100% immunogen sequence identity) | |
IgG2a Monoclonal [BH6] | |
Unconjugated | |
Protein G purified | |
Unmodified |
Complement C3 antibody was raised against human Activated C3. | |
Recognizes human C3 neo-epitope expressed on the cleavage fragments of C3b, iC3b, and C3c, but not C3dg and C3f. | |
Suitable for use in ELISA and Immunohistochemistry. ELISA: detects and quantifies C3 activation products in human plasma, synovial fluid, and cerebrospinal fluid. Immunohistochemistry (paraffin, frozen): 1:50. |
Supplied as as liquid in PBS, 0.1% BSA, 0.02% sodium azide | |
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. | |
For research use only. |
C3 Antibody, AHUS5 Antibody, ARMD9 Antibody, Complement component C3 Antibody, CPAMD1 Antibody, Complement C3 Antibody, ASP Antibody, Complement component 3 Antibody
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process.