Mouse CLEC7A / Dectin 1

Rat

Mouse (tested or 100% immunogen sequence identity)

IgG2b Monoclonal

2A11

Unconjugated

Protein G purified

Low Endotoxin. Also available Unmodified.

Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1.

Recognizes murine beta-glucan receptor, also known as Dectin-1. Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells. As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macrophages via the protein tyrosine kinase known as Syk. Inhibits the binding of zymosan to macrophages via the beta-glucan receptor. The low endotoxin version is recommended for functional studies.

• IHC - Frozen
• Immunoprecipitation
• Flow Cytometry (1:10 - 1:50)

• IHC - Paraffin
• IHC - Resin

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

PBS

Store at 4°C. Do not freeze. Store undiluted. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9BXN2 NCBI: NM_022570 NP_072092.2