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CLDN10 / Claudin 10 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.
Gene Name: | claudin 10 |
Family/Subfamily: | Claudin , not assigned-Claudin |
Synonyms: | CLDN10, CPETRL3, Claudin 10, OSP-L, OSP-like protein, Claudin-10 |
Target Sequences: | NM_006984 NP_008915.1 P78369 |
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