Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity. Appierto V, Tiberio P, Cavadini E, Casalini P, Cappelletti G, Formelli F. Molecular cancer therapeutics. 2009 8:3360-8.
Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG. Foraker AB, Camus SM, Evans TM, Majeed SR, Chen CY, Taner SB, Corra IR, Doxsey SJ, Brodsky FM. The Journal of cell biology. 2012 198:591-605.
CKAP5 / ch-TOG is a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly.
HepG2 cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit polyclonal antibody against ch-TOG. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection
Requested From: United States
Date Requested: 2/22/2017