CHFR

checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

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Products

Antibodies (22)

Proteins (9)

Type

Over-Expression Lysate (6)

Primary (22)

Recombinant (3)

Target

CHFR (31)

Reactivity

Human (22)

Mouse (9)

Rat (7)

Bat (1)

Bovine (1)

Chicken (1)

Chimpanzee (3)

Dog (1)

Gibbon (3)

Guinea pig (3)

Horse (1)

Monkey (4)

Orangutan (3)

Pig (1)

Rabbit (4)

Xenopus (1)

Zebrafish (4)

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Application

IHC (8)

IHC-P (6)

WB (18)

ELISA (14)

IF (1)

Peptide-ELISA (2)

RNAi (1)

Host

rabbit (20)

mouse (1)

goat (1)

Product Group

IHCPlus (1)

Isotype

IgG (19)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (21)

Clone

1H3-A12 (1)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (11)

Epitope

aa476-504 (7)

aa36-85 (4)

Internal (1)

aa651-663 (1)

Publications

No (31)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (7)

Species

Human (6)

Source

293T Cells (3)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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CHFR Antibody (aa36-85) LS-B5739

Antibody:

CHFR Rabbit anti-Human Polyclonal (aa36-85) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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CHFR Antibody (aa36-85, HRP) LS-C444875

Antibody:

CHFR Rabbit anti-Human Polyclonal (aa36-85) (HRP) Antibody

Reactivity:

Zebrafish, Rabbit, Mouse, Guinea pig, Rat, Human, Monkey, Chimpanzee, Orangutan, Gibbon

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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CHFR Antibody (aa36-85, Biotin) LS-C444873

Antibody:

CHFR Rabbit anti-Human Polyclonal (aa36-85) (Biotin) Antibody

Reactivity:

Zebrafish, Rabbit, Mouse, Guinea pig, Rat, Human, Monkey, Chimpanzee, Orangutan, Gibbon

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

CHFR Antibody (aa36-85, FITC) LS-C444876

Antibody:

CHFR Rabbit anti-Human Polyclonal (aa36-85) (FITC) Antibody

Reactivity:

Zebrafish, Rabbit, Mouse, Guinea pig, Rat, Human, Monkey, Chimpanzee, Orangutan, Gibbon

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

CHFR Antibody (clone 1H3-A12) LS-C133778

Antibody:

CHFR Mouse anti-Human Monoclonal (1H3-A12) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, RNAi, WB

Format:

Unconjugated

Price:

100 µg/$423

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CHFR Antibody LS-C501404

Antibody:

CHFR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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CHFR Antibody (HRP) LS-C501407

Antibody:

CHFR Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

CHFR Antibody (Biotin) LS-C501425

Antibody:

CHFR Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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CHFR Antibody (FITC) LS-C501403

Antibody:

CHFR Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

CHFR Antibody LS-C805621

Antibody:

CHFR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

CHFR Antibody LS-C753671

Antibody:

CHFR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

CHFR Antibody (aa651-663) LS-C54652

Antibody:

CHFR Goat anti-Human Polyclonal (aa651-663) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Bovine, Bat, Rat, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$503

Select

CHFR Antibody (Internal) LS-C382686

Antibody:

CHFR Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

CHFR Antibody (aa476-504) LS-C320350

Antibody:

CHFR Rabbit anti-Human Polyclonal (aa476-504) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

CHFR Antibody (aa476-504, Biotin) LS-C254727

Antibody:

CHFR Rabbit anti-Human Polyclonal (aa476-504) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

CHFR Antibody (aa476-504, FITC) LS-C254729

Antibody:

CHFR Rabbit anti-Human Polyclonal (aa476-504) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

CHFR Antibody (aa476-504, APC) LS-C254728

Antibody:

CHFR Rabbit anti-Human Polyclonal (aa476-504) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

CHFR Antibody (aa476-504, PE) LS-C254731

Antibody:

CHFR Rabbit anti-Human Polyclonal (aa476-504) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

CHFR Antibody (aa476-504, Azide-free, HRP) LS-C254730

Antibody:

CHFR Rabbit anti-Human Polyclonal (aa476-504) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

CHFR Antibody LS-C824863

Antibody:

CHFR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

CHFR Antibody (aa476-504) LS-C168728

Antibody:

CHFR Rabbit anti-Human Polyclonal (aa476-504) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

CHFR Antibody LS-C497157

Antibody:

CHFR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

CHFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128242

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.7 kDa

Price:

100 µg/$494

Select

CHFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128303

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.2 kDa

Price:

100 µg/$494

Select

CHFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111880

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69 kDa

Price:

100 µg/$710

Viewing 1-25 of 31 product results

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