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CHD4 belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Name: | chromodomain helicase DNA binding protein 4 |
Synonyms: | CHD4, ATP-dependent helicase CHD4, CHD-4, Mi-2b, Mi2-BETA |
Target Sequences: | NM_001273 NP_001264.2 Q14839 |
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