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CEP170 is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.
Gene Name: | centrosomal protein 170kDa |
Synonyms: | CEP170, Centrosomal protein 170kDa, Centrosomal protein of 170 kDa, FAM68A, KAB, KIAA0470, KARP1-binding protein, KARP-1-binding protein, XRCC5 binding protein |
Target Sequences: | NM_014812 NP_055627.2 Q5SW79 |
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