Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Specificity and Use
CENPB antibody was raised against the epitope recognized maps to a region between residues 540 and the C-terminus (residue 599) of human Centromere Protein B using the numbering given in entry SwissProt entry P07199 (GeneID 1059).
Species cross-reactivity: Human. Other species have not been tested.
CENPB Antibody, Centromere autoantigen B Antibody, Centromere protein B (80kD) Antibody, Centromere protein B Antibody, Major centromere autoantigen B Antibody, CENP-B Antibody, Centromere protein B, 80kDa Antibody
CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA.